Ulrike Dydak1,2, Jonathan M. Nixon1,
Mario Dzemidzic3, Harish Sai Karne4, Amit Anand4
1School of Health Sciences, Purdue
University, West Lafayette, IN, United States; 2Department of
Radiology and Imaging Sciences, Indiana University School of Medicine,
Indianapolis, IN, United States; 3Department of Neurology, Indiana
University School of Medicine, Indianapolis, IN, United States; 4Department
of Psychiatry, Indiana University School of Medicine, Indianapolis, IN,
United States
Changes
in brain metabolism were studied in medication-free patients with bipolar and
unipolar disorder and compared to matched healthy controls. 2D MRSI data
acquired in an axial slice including thalamus, anterior and posterior
cingulate cortex (ACC & PCC) were analyzed using LCModel. Significant decreases
in NAA/ creatine were found in bipolar patients compared to healthy controls
in the right thalamus and right ACC. Furthermore, when comparing bipolar to
unipolar patients, significant decreases in the choline/creatine ratio were
observed in the right thalamus. No significant group differences were found
in the PCC nor any of the left hemisphere regions of interest.