Maria
Engstrm1, Thomas Karlsson2, Anne-Marie Landtblom3
1IMH/Radiological Sciences/CMIV,
Linkping University, Linkping, Sweden; 2Behavioural Sciences and
Learning/CMIV, Linkping University, Linkping, Sweden; 3IKE/Neurology/CMIV, Linkping
University, Linkping, Sweden
Functional
connectivity of intrisic fluctuations in the resting brain was investigated in order to scrutinize the
neuropathology of patients with periodic hypersomnia, Kleine-Levin syndrome
(KLS). The main findings were that KLS patients exhibited increased coupling
in the middle and inferior frontal gyri (Brocas area) and decreased coupling
in the left superior temporal gyrus (Wernickes area) as compared to healthy
controls. In a previous study we showed working memory dysfunction
accompanied by thalamic and left prefrontal hypoactivity in KLS. These
findings suggest aberrant function in the thalamo-cortical networks, which
might explain the patients symptoms.