Alterations of Brain Structure and Functional Connectivity in Chronic Cocaine Users

Hong Gu¹, Xiujuan Geng¹, Betty Jo Salmeron¹, Thomas J. Ross¹, Elliot A. Stein¹, Yihong Yang¹

Cocaine dependence is associated with various deficits in brain function, structure and metabolism. In this study, anatomic abnormalities and their relationship to functional network integrity in cocaine users were examined using voxel-based morphometry and resting-state functional connectivity analyses. Our data show that regions with reduced gray matter volume are closely associated with altered functional connectivity strength in corresponding brain networks.