Henry Ho Ching Tam1, David J. Collins2,
Gina Brown1, Ian Chau3, David Cunningham3,
Martin O. Leach2,
Dow-Mu Koh1
1Department of Radiology, Royal Marsden
NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2CRUK-EPSRC
Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United
Kingdom; 3Department of Medical Oncology (Gastrointestinal), Royal
Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
We
report the use of DW-MRI for assessing response to chemotherapy and long-term
outcome in patients with colorectal hepatic metastasis. Non-responders were
found to have a higher pre-treatment apparent diffusion coefficient (ADC).
High pre-treatment ADC was also associated with a shorter progression free
survival time, independent of response to chemotherapy and other prognostic
factors. This study demonstrates the potential of DW-MRI as a biologically
relevant response and prognostic biomarker.