Gerald B. Matson1,2, Karl Young1,3, Lana G. Kaiser1,3
1CIND, Veterans Affairs Medical Center, San Francisco, CA 94121, USA; 2Pharmaceutical Chemistry, University of California, San Francisco, CA, USA; 3Radiology, University of California, San Francisco, San Francisco, CA, USA
Localized in vivo spectroscopy at high magnetic field strength (> 3 T) is susceptible to localization artifacts such as the chemical shift artifact and the spatial interference artifact for J-coupled spins. This latter artifact results in regions of anomalous phase for J-coupled spins. The use of selective RF pulses with increased bandwidth can minimize the signals with anomalous phase, while further suppression of anomalous phase signals can be accomplished with selective saturation pulses. Here we demonstrate through examples that optimal control methods can provide new, improved bandwidth localization and saturation pulses for improved localized spectroscopy at high field.