Christian M. Zechmann1, Khurram Aftab1, Patrik Zamecnik1, Frederik L. Giesel1, Christian Thieke2, Jurgen Ftterer3, Anette Kopp-Schneider4, Stefan Delorme5
1Radiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Wuerttemberg, Germany; 2Radiotherapy, German Cancer Research Center (DKFZ), Heidelberg, Baden-Wuerttemberg, Germany; 3Radiology, University Medical Centre Nijmegen, Nijmegen, Netherlands; 4Biostatistics, German Cancer Research Center (DKFZ),, Heidelberg, Baden-Wuerttemberg, Germany; 5Radiology, German Cancer Research Center (DKFZ),, Heidelberg, Baden-Wuerttemberg, Germany
The shrinking effect of androgen deprivation therapy (ADT) on prostate volume is a known finding but data on volume changes during radiotherapy is inconsistent. We examined patients with and without ADT undergoing intensity modulated radiotherapy (IMRT). Patients undergoing IMRT show definite prostate shrinkage in T2w MRI. The rate is slowed down after 6 months in both groups, whereas the volume reduction is significantly larger in patients without ADT. Nevertheless there is no adding effect of ADT+IMRT vs. IMRT alone.