Dynamic-Contrast Enhanced MRI and MR-Guided Biopsy in the Detection of Local Recurrence After Radiation Therapy for Prostate Cancer

Derya Yakar¹, Thomas Hambrock, Henkjan Huisman, Tom Scheenen, Christina Hulsbergen-vandeKaa, Emile van Lin, Jelle Barentsz, Jurgen Ftterer

Currently used techniques in the detection of prostate cancer recurrence after radiotherapy are inadequate. We studied the potential of Dynamic-Contrast Enhanced (DCE) MRI in combination with MR guided biopsy of tumor suspicious regions (TSR) to improve detection of local prostate cancer recurrence following radiotherapy. 15 Patients with 3 consecutive rises in prostate specific antigen (PSA) level after radiotherapy underwent MRI at 3T. TSR were determined from T2-weighted MR images and DCE-MR images. An MR-guided biopsy was taken from these TSR. Prostate cancer was found in 13/15 patients. 22/29 TSR were positive for tumor on biopsy.