Anup Singh1, Mohammad Haris1, Erin McArdle1, Matthew Sochor1, Matthew Fenty1, Christos Davatzikos2, John Q. Trojanowski3, Elias R. Melhem, Christopher M. Clark4, Ravinder Reddy1, Arijitt Borthakur1
1MMRRCC, Radiology, University of Pennsylvania, Philadephia, PA, USA; 2SBIA, Radiology, University of Pennsylvania, Philadephia, PA, USA; 3Department of Pathology & Lab Medicine, University of Pennsylvania, Philadephia, PA, USA; 4Department of Neurology, University of Pennsylvania, Philadephia, PA, USA
Structural neuroimaging has the potential to play an important role in the early diagnosis of both AD and PD. In the current study, we measured the T1rho (T1ρ) value in MTL in the brain of control, Parkinson's disease (PD) and Alzheimer's disease (AD). T1ρ was significantly increased in AD compared to control and PD. The PD individuals showed decreased T1ρ compared to control. We conclude that the serial measurement of T1ρ in both AD and PD may provide the nature of disease progression and would contribute to their early diagnosis in the future.