Stephen Jones1, Gene Barnett2, Jeffrey L. Sunshine3, Mark Griswold3, Andrew Sloan4, Micheal D. Phillips5, Richard Tyc6, Mark Torchia7
1Imaging Institute, Cleveland Clinic, Cleveland, OH, USA; 2Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; 3Department of Radiology, University Hospitals Case Medical Center, Cleveland, OH; 4Department of Neurosurgery, University Hospitals Case Medical Center, Cleveland, OH; 5Imaging Institute, Cleveland Clinic, Cleveland , OH, USA; 6Monteris Medical Inc, Winnipeg, Manitoba, Canada; 7Department of surgery, University of Manitoba, Winnipeg, Manitoba, Canada
Glioblastoma (GB) is the most frequent primary brain malignancy in adults, usually resulting in death in 1-2 years despite decades of research. Although treatments such as surgery, chemotherapy, and radiation extend survival several months, recurrence is inevitable making minimally invasive therapies attractive. We describe the first human application of laser interstitial thermal therapy (LITT) of a GBM using the Monteris AutoLITT system. This system is unique in using real-time MRI thermometry to contour treatment precisely within the confines of the tumor. The AutoLITT produced thermal lesion appeared to stabilize after 48 hours and was accurately predicted by the AutoLITT software.