Abstract #2523

Image-Guided Modulation of Regional Brain Function Mediated by Focused Ultrasound

Seung-Schik Yoo¹, Alexander Bystritsky^1,2, Jong-Hwan Lee¹, YongZhi Zhang¹, Krisztina Fischer¹, Wonhye Lee¹, Nathan McDannold¹, Ferenc A. Jolesz¹

¹Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; ²Psychiatry, UCLA, Los Angeles, CA, USA

Utilizing the minimally-invasive nature of the Focused ultrasound (FUS), selective modulation of regional neural activity in brain was sought after, and we found early evidence that FUS, as administered in train of pulses (i.e. focused ultrasound pulse: FUP), mediated reversible modulation of cortical activity in animal model.