Yuqing Huang1, Zhong Chen1,2, Shuhui Cai1, Jianhui Zhong2
1Physics Department, Xiamen University, Xiamen, Fujian, China; 2Radiology and Biomedical Engineering, University of Rochester, Rochester, NY, USA
In in vivo NMR study, inhomogeneous line broadening due to magnetic susceptibility gradients and intensive water signal often leads to severe spectral peak overlapping and weak signal obstructing. In this abstract, a new pulse sequence based on intermolecular single-quantum coherences (iSQC) was presented for high-resolution spectra from biological tissues. Several heterogeneous biological samples were measured to test the feasibility of the pulse sequence. The experimental results indicate that the method is a useful tool of high-resolution MRS for heterogeneous biological samples.