Eric Albert Mellon1, Seung Cheol Lee1, Sungheon Kim2, Ravinder Reddy1, Jerry D. Glickson1
1Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Radiology, New York University, New York, NY, USA
Lactate is an important biomarker of ischemia, malignancy and cancer response to treatment. But, MR lactate mapping has been difficult due to the overlapping 1.3ppm lipid resonance. Here, using clinical 3T MRI hardware, a combination of selective Multiple Quantum Coherence (SelMQC) with 2D phase and 1D Hadamard encoding (HDMD-SelMQC-CSI) selects lactate. Hadamard selection is demonstrated in the non-Hodgkins lymphoma (NHL) of a patient. Lactate is then imaged in a human NHL in only 5 minutes. Also, increases in lactate are shown during muscle ischemia. This technique is now open for identification of tumor response to therapy and studies of ischemia.