Alyaa Hussein Elzibak1,2, Jeff Fortuna2,3, John F. MacGregor3, Colm Boylan4, Michael D. Noseworthy2,5
1Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada; 2Brain-Body Institute, St. Joseph's Healthcare, Hamilton, Ontario, Canada; 3Chemical Engineering, McMaster University, Hamilton, Ontario, Canada; 4Diagnostic Imaging, St. Joseph's Healthcare, Hamilton, Ontario, Canada; 5Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada
We developed a liver challenge procedure that relies on modulating the BOLD signal with hyperoxia and meal intake. Temporal BOLD data analysis using partial least squares (PLS) was superior to a traditional general linear model (GLM). We show how the method can differentiate healthy from diseased liver tissue.