Inflammation Imaging of Atherosclerosis: MRI of Iron Oxide-Labelled Macrophages Trafficking in ApoE2 (KI) Mice Lesions

Amine Bessaad¹, Monica Sigovan¹, Hasan Alsaid¹, Genvive De Souza1¹, Nicolas Provost², Zoher Majd², Christine Menager³, Norbert Nighoghossian1¹, Serge Nataf⁴, Emmanuelle Canet-Soulas1¹

MRI caracterisation of atheroma plaque in aortic arch of mice ApoE2 (K.I) by using Anionic Magnetic Nano Particules of iron oxide labelled macrophages and assessment of inflammatory status of atheroma plaques by follow up during 3 days post-contrast, allows us to detect the macrophages after migration distributed in intimal and/or adventitial localization. this is promising for vectorization and assessement of traitement accuracy