Simultaneous Quantitation of T2 and Concentration of Vitamin C and GSH in the Human Brain in Vivo Using Multiple Echo Time Double Editing with MEGA-PRESS at 4 and 7 T

Uzay Emir¹, Malgorzata Marjanska¹, Dinesh Deelchand¹, Pierre-Gilles Henry¹, Ivan Tkac¹, Melissa Terpstra¹

Double Edited MEGA-PRESS spectra were detected at multiple TE in the human brain to measure T2 of Asc and GSH. Data from 22 subjects studied at 4 T were pooled to measure a 50 ms T2 for GSH (95% CI 41-62). The Asc T2 was not determined due to contamination by co-edited resonances. To our knowledge, this is the first time the T2 of GSH has been reported. Spectra measured at several TE in the human brain at 7 T suggest that this methodology can be utilized to measure the Asc and GSH T2 at 7 T.