Abstract #3628

Tsuda N, Tsuji T, Kato N, Fukuda Y, Ando K, Ishikura R, Nakao N

We investigated the potential of superparamagnetic iron oxide (SPIO) in the differential diagnosis of bone metastasis and inflammation using the animal models. VX2 tumor cells or croton oil were injected into the femora of rabbits. SPIO was intravenously injected at a dose of 8 micro mol Fe/kg. The signal intensity of tumor did not change after a SPIO injection, whereas signal intensity of normal bone marrow and inflammation decreased. Our results showed that SPIO was useful to detect bone marrow tumors. In addition, SPIO may have potential in the differential diagnosis of bone metastasis and inflammation.