Abstract #1796

Urioste A, Joe B, Vahidi K, Gibbs J, Lu Y, Hylton N, Siraj Z, Proctor E

MRI breast tumor volume has recently been shown to be predictive of length of recurrence free survival (LRFS) in breast cancer patients undergoing neoadjuvant chemotherapy. This study evaluates a software package (CADstreamTM, Confirma, Inc.) for automated measurement of serial breast MRI tumor volumes in response to treatment and compares results to established in-house software. CADstreamTM produced similar results to those reported previously using in-house software (correlation coefficients ranged from 0.71 to 0.95, p<0.0003 for all visits). The reproducibility of results using commercially-available software supports the robustness of volumetric measurements of tumor response as a surrogate endpoint for survival outcomes.