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Abstract #8176

APT-Weighted MRI of Cancer & Ischemia

Hye-Young Heo1,2

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Amide proton transfer-weighted (APTw) imaging, a variant of the CEST-based molecular MRI technique, is based on the chemical exchange between free bulk water protons and the amide protons (-NH) of mobile proteins and peptides. Theoretically, the APTw-MRI signal relies mainly on the mobile amide proton concentration and amide proton exchange rate which are related to tissue pH. Therefore, APTw-MRI has the potential to detect brain tumors (where many proteins are overexpressed) and ischemic strokes (where pH drop). Early pre-clinical and clinical data suggest that APTw imaging has unique features by which to detect and characterize brain tumors and strokes.

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