In light of the recent demand for new tools that will allow better investigation of complex biological processes, a new field has evolved at the interfaces of synthetic chemistry, molecular engineering, and cellular imaging. Label-free molecular probes based on diaCEST agents for molecular and cellular imaging applications provide the scientific community with unprecedented versatility to monitor wide range of biological events in health and disease. Although diaCEST molecular sensors should be further developed, their performances marks the dawn of a new scientific era for molecular and cellular MRI
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