Loading Significantly Influences the Zonal T1 of Medial Tibial Cartilage Topographically
Ji Hyun Lee1,2, Farid Badar1,2, John Matyas3, and Yang Xia1,2
1Physics, Oakland University, Rochester, MI, United States, 2Center for Biomedial Research, Oakland University, Rochester, MI, United States, 3Univeristy of Calgary, Calgary, AB, Canada
This study aims to quantify the
loading-modified T1 in articular cartilage using a canine model of early osteoarthritis
(OA) at different degradation stages, at a 17.6µm resolution and with the use
of Gd contrast agent. Both lesion and mechanical compression were found to alter
T1 in cartilage at each sub-tissue zone and topographically, which provide a
better understanding of the MRI properties of cartilage during joint loading.
This result could help to design effective protocols in clinical MRI to better
detect and manage the osteoarthritic diseases.
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