Simultaneous Extraction of ADC and T2: Validation of Quantified DESS Sequence at 3T and 7T
Forrest Howell1, Haonan Wang1, Daniel Park2, Meredith Taylor1, Bragi Sveinsson3, and Neal Bangerter1
1Electrical Engineering, Brigham Young University, Provo, UT, United States, 2Biomedical Imaging, Electrical Engineering, University of Oxford, Oxford, United Kingdom, 3Radioligy, Stanford University, Palo Alto, CA, United States
A modification of the
dual-echo steady state (DESS) pulse sequence was recently proposed that allows
the extraction of both T2 and apparent diffusion coefficient (ADC) maps from a
pair of DESS acquisitions (termed quantitative DESS, or qDESS).
A careful validation of the
accuracy of the qDESS T2 and ADC estimates has not yet been performed.
The qDESS sequence produces accurate, high-resolution ADC and
T2 maps. This is especially notable at 7T, where transmit B1
inhomogeneity makes it very difficult to produce reasonable T2 maps using
typical multi-echo spin echo techniques. The qDESS technique shows great
promise in providing both high-resolution morphological data and maps of T2 and
ADC at 3 and 7 Tesla.
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