Abstract #4456

R1 Relaxation Mapping of Manganese Uptake and Wash-out in a Non-Human Primate Model of Chronic Mn Exposure

Chien-Lin Yeh^1,2, Jennifer McGlothan Dziedzic³, Tomas R. Guilarte³, and Ulrike Dydak^2,4

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ³Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, United States, ⁴School of Health Sciences, Purdue University, West lafayette, IN, United States

High exposure to manganese (Mn) causes motor impairments resembling Parkinson’s disease. Using R1 mapping we investigated the dynamics of brain Mn accumulation during and after chronic manganese exposure in nonhuman primates. The R1 in whole brain displayed a significant increase after 27-41 wks of exposure. The visual cortex was found to have continuous Mn accumulation over exposure duration, while R1 of substantia nigra was decrease at 66-81 wks. Some select brain areas still show hyperintensities ten months after cessation of exposure. Understanding the regional uptake and retention may help elucidating the relation of Mn exposure to neurological symptoms.

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