Abstract #4455

Radiation induced sub-acute, early delayed and late delayed changes in hippocampus: A successive MRS, DTI and behavioral evaluation after whole body radiation

Poonam Rana¹, Mamta Arya Gupta¹, Seenu Haridas², Kailash Manda², B S Hemanth Kumar¹, and Subash Khushu¹

¹NMR Research Centre, INMAS, Delhi, India, ²Division of Radiation Biosciences, INMAS, Delhi, India

Nuclear accidents or terrorist activities may lead to moderate dose whole body radiation exposure to a mass population. Whole body radiation exposure may influence brain function but it has not been extensively studied. Present study was conducted on mice to look for whole body radiation induced delayed behavioural, metabolic and microstructural changes. The results illustrated changes in recognition memory, MRS and MD values till 8 months post-irradiation. At later time points (10 and 12 months post-irradiation), no profound effect of radiation exposure was observed which indicates that 5Gy whole body radiation dose exposure does not have late delayed radiation injury.

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