Abstract #4441

A step towards developing MR elastography and diffusion tensor imaging as complementary MR tools to improve the management of hydrocephalus.

Lauriane Jugé ^1,2, Alice C. Pong¹, Andre Bongers³, Ralph Sinkus⁴, Lynne E. Bilston^1,5, and Shaokoon Cheng⁶

¹Neuroscience Research Australia, Randwick, NSW, Australia, ²School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia, ³Biological Resources Imaging Laboratory, University of New South Wales, Kensington, NSW, Australia, ⁴BHF Centre of Excellence, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ⁵Prince of Wales Clinical School, University of New South Wales, Kensington, NSW, Australia, ⁶Department of Engineering, Faculty of Science, Macquarie University, North Ryde, NSW, Australia

Hydrocephalus is characterised by enlarged ventricles resulting in compression of surrounding tissues. Conventional imaging techniques depict ventricle size accurately. However, they are limited to detect changes in brain microstructure. The aim of this work was to quantify changes in brain mechanical and diffusion properties during the development of hydrocephalus in rats, using MR Elastography and Diffusion Tensor Imaging. Results showed that both techniques have the potential to be complementary imaging tools for tracking the effects of hydrocephalus on the tissue microstructure and provided new insights on how the brain changes during the course of the disease.

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