Xin Hong1, Marta Garcia-Miralles2, Ling Yun Yeow1, Xuan Vinh To1, Benjamin Chaik Meng Yeo1, Fiftarina Puspitasari1, Katrianne Bethia Koh2, Liang Juin Tan2, Mahmoud Abdul Pouladi2,3, and Kai-Hsiang Chuang1
1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore, 2Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore, Singapore, 3Department of Medicine, National University of Singapore, Singapore, Singapore
T2
weighted structural and diffusion MRI together with behavioral tests were
conducted to evaluate the effects of memantine treatment in YAC128 mouse model
of Huntington disease. In low-dose (2 mg/kg)-treated YAC128 mice, cognitive
functions improved, and increased fractional anisotropy was found in major fiber
tracts including the corpus callosum, anterior commissure, and internal
capsule. No significant gray matter volume change was detected in treatment
groups, though the relative caudate putamen volume showed increasing trend with
dose. Our results suggest that low dose memantine treatment had protective
effects on white matter in YAC128 mice.
