Abstract #4388

Characterization of Regional and Longitudinal Changes in Z-spectra of Spinal Cord Injury

Feng Wang^1,2, Zhongliang Zu^1,2, Tung-Lin Wu^2,3, John C. Gore^1,2,3, and Li Min Chen^1,2

¹Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Non-human primates provide a valuable pre-clinical model for studying spinal cord injuries. Here we examine the fingerprints in the Z-spectra of abnormal tissues and cysts surrounding the lesion site after spinal cord injury, regionally and longitudinally. Characteristic chemical exchange saturation transfer (CEST) and nuclear Overhauser enhancement (NOE) effects extracted from Z-spectra may enable the non-invasive assessment of spontaneous recovery from traumatic injury.

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