Abstract #4384

Arterial Spin Labeling MRI Evaluation of Cerebrovascular Reserve with Acetazolamide in Patients with Sickle Cell Disease

Lena Václavů¹, Henk Mutsaerts², Pim van Ooij¹, Bart J Biemond³, John C Wood⁴, Charles BLM Majoie¹, Ed van Bavel⁵, and Aart J Nederveen¹

¹Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, ⁴Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁵Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

Arterial spin labelling perfusion MRI was employed with an acetazolamide challenge to probe the cerebrovascular physiology in patients with sickle cell disease and matched controls. Cerebral blood flow was estimated at baseline and cerebrovascular reserve(CVR) was calculated after vasodilation with acetazolamide. We found that patients had limited CVR compared to controls, and that the patients with the highest CBF at baseline also had the smallest response to acetazolamide. ASL-based CBF measurements with ACZ showed robust CVR results indicating the cerebral hemodynamics of some patients may be impaired.

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