Multiparametric MR imaging of oxygen metabolism and angiogenesis for detection of recurrence or grade increase in glioma patients
Andreas Stadlbauer1, Max Zimmermann1, Karl Rössler1, Stefan Oberndorfer2, Michael Buchfelder1, and Gertraud Heinz3
1Department of Neurosurgery, University of Erlangen, Erlangen, Germany, 2Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria, 3Department of Radiology, University Clinic of St. Pölten, St. Pölten, Austria
Early detection of recurrence is crucial in patient
care, but differentiation of treatment related necrosis from recurrent neoplasm
is often difficult with conventional MRI (cMRI). We evaluated the usefulness
for glioma recurrence grade increase detection of a multiparametric MRI for combined
exanimation of oxygen metabolism and microvessel architecture. Forty-one
patients with suspected recurrent glioma and one patient under antiangiogenic
therapy were examined using vascular architecture mapping (VAM) and
multiparametric quantitative BOLD (mp-qBOLD). 57% of LGG-patients, 22% of
glioma WHO°III, and 32% of glioblastoma patients which were diagnosed as
unsuspicious showed changes in oxygen metabolism and microvasculature indicative
for recurrence.
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