Whole-brain volume alteration and its correlation with anxiety severity in patients with obsessive compulsive disorder and generalized anxiety disorder
Gwang-Won Kim1, Chung-Man Moon1, Tae-Hoon Kim1, and Gwang-Woo Jeong1,2
1Research Institute of Medical Imaging, Chonnam National University Medical School, Gwang-ju, Korea, Republic of, 2Department of Radiology, Chonnam National University Medical School, Gwang-ju, Korea, Republic of
Obsessive
compulsive disorder (OCD) and generalized anxiety disorder (GAD) are associated
with abnormalities in the processing and regulation of anxiety. The purpose of
this study was to evaluate gray matter (GM) and white matter (WM) volume
alterations over whole-brain structures in healthy controls vs. patients with
OCD vs. GAD using voxel-based morphometry (VBM), and further to assess the
correlations of the GM and WM volume variations with the scores for anxiety
severity in OCD and GAD.
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