Abstract #4159

Increase of grey matter following bifrontal rTMS in drug resistant major depressive disorder patients: A VBM study

Elisa Kallioniemi^1,2, Mervi Könönen^1,3, Juhana Hakumäki³, Esa Mervaala¹, Heimo Viinamäki⁴, Ritva Vanninen³, and Minna Valkonen-Korhonen⁴

¹Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland, ²Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ³Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland, ⁴Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland

Repetitive transcranial magnetic stimulation (rTMS) is able to induce long-term excitatory and inhibitory effects on cortical functions if applied repeatedly over several days. Thus, rTMS possesses a great potential in therapeutic applications and several promising therapies have already been developed. Whether rTMS causes structural neuroplasticity, however, remains mainly unknown. In this study, we found that bifrontal rTMS applied to dorsolateral prefrontal cortex (DLPFC) elicited structural changes in major depressive disorder patients. The increase in grey matter was found in the right post- and precentral gyri, which are both functionally connected to DLPFC.

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