Abstract #4153

Alterations of neural correlates in drug-naïve first episode pediatric patients with posttraumatic stress disorder: An optimized voxel-based morphometry study

Lei Li¹, Xinyu Hu¹, Du Lei¹, Xiaoqi Huang¹, and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of

The current study used voxel-based morphometry (VBM)-diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) algorithm to investigate the gray matter abnormalities in drug-naïve first-episode pediatric patients with posttraumatic stress disorder (PTSD) using high resolution structural MRI. Meanwhile, we investigated the association between altered neural correlates and symptom severity as measured by clinician-administered PTSD scale (CAPS) and PTSD checklist (PCL) scores with the age as a covariate. The current study provided the preliminary evidence that the intrinsic abnormalities of neural correlates in pediatric PTSD patients were mainly in fear circuit and default mode network.

This abstract and the presentation materials are available to members only; a login is required.

Join Here