Abstract #4152

Alteration of white matter microstructure within the reward circuit revealed by neurite orientation dispersion and density imaging (NODDI)

Kouhei Kamiya¹, Naohiro Okada², Yuichi Suzuki³, Ryusuke Irie¹, Takatoshi Kubo¹, Yudai Nakai⁴, Yasumasa Nippashi¹, Daisuke Koshiyama², Kentaro Morita², Kingo Sawada², Yoshihiro Satomura², Shinsuke Koike^2,5, Harushi Mori¹, Akira Kunimatsu¹, Kiyoto Kasai², and Kuni Ohtomo¹

¹The Department of Radiology, The University of Tokyo, Tokyo, Japan, ²The Department of Neuropsychiatry, The University of Tokyo, Tokyo, Japan, ³The Department of Radiological Technology, The University of Tokyo Hospital, Tokyo, Japan, ⁴The Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan, ⁵Ofﬁce for Mental Health Support, Division for Counseling and Support, The University of Tokyo, Tokyo, Japan

This study aimed to investigate the brain microstructural alteration in patients with major depressive disorder (MDD) using neurite orientation dispersion and density imaging (NODDI). Nineteen MDD patients and 13 controls were involved. The TBSS analyses revealed significant increase in orientation dispersion index (ODI) in patients with MDD, distributed in bilateral frontal lobes and right occipital lobe, right internal capsule, bilateral thalamus and hypothalamus, right nucleus accumbens, and midbrain tegmentum, suggesting involvement of the reward circuit. The neurite density was not significantly altered, arousing interest on further study focusing on treatment response, whether the ODI increase is reversible or not.

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