Abstract #4025

Grey and white matter signal separation in the single voxel NMR spectroscopy at 7T

Donghyun Hong¹, Jack JA van Asten², Seyedmorteza Rohani Rankouhi¹, Jan-Willem Thielen¹, and David G. Norris^1,3

¹Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, ²Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ³Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

GABA spectroscopy has two potential confounds widely ignored by the spectroscopic community: 1) a potential 5-10Hz frequency shift between grey and white matter shown in imaging experiment and 2) the fact that the GABA is circa 9 times more concentrated in grey matter. To investigate whether these confounds could affect GABA spectroscopy at 7T, we compute grey and white matter lineshapes by frequency mapping. We found a slight frequency shift and lineshape which can be ignored. Hence, we conclude that we can probably safely use a single lineshape for fitting using LCModel.

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