Rodolfo Abreu1, Sandro Nunes1, Alberto Leal2, and Patrícia Figueiredo1
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal, 2Department of Neurophysiology, Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal
We propose a physiological noise model where
respiratory-induced BOLD signal fluctuations were extracted from a surrogate of
the respiratory signal estimated by Empirical Mode Decomposition. We optimized this
model on a subject-specific basis, and evaluate its impact EEG-correlated fMRI
mapping of epileptic networks, by comparing the epileptic maps obtained with
and without physiological noise correction. This assessment was performed in
terms of specificity and sensitivity, having been obtained not only substantial
improvements for both measures, but also plausible and patients' semiology
concordant epileptic networks.
