Abstract #3807

Effects of Hyperglycemia and Hyperinsulinemia on Amplitude of Low Frequency Fluctuations in Medial Frontal and Posterior Cingulate Cortices in Healthy Non-Diabetic Subjects

Nicolas R. Bolo^1,2, Alan M. Jacobson³, Brandon Hager¹, Gail Musen^2,4, Matcheri Keshavan^1,2, and Donald C. Simonson^5,6

¹Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States, ²Psychiatry, Harvard Medical School, Boston, MA, United States, ³Research Institute, Winthrop University Hospital, Mineola, NY, United States, ⁴Research Division, Joslin Diabetes Center, Boston, MA, United States, ⁵Division of Endocrinology, Brigham and Women's Hospital, Boston, MA, United States, ⁶Harvard Medical School, Boston, MA, United States

Our goal is to elucidate the independent effects of hyperglycemia and hyperinsulinemia on brain function. We measured whole-brain amplitude of low frequency fluctuations (ALFF) in slow-band 5 (SB5: 0.01-0.027Hz) and slow-band 4 (SB4: 0.027-0.073Hz) in 10 healthy non-diabetic subjects using resting state fMRI during fasting baseline euglycemia (EU), hyperglycemia (HG) and euglycemic hyperinsulinemia (EU-HI). SB5 fractional ALFF was decreased in the left medial frontal gyrus and right posterior cingulate/cuneus/precuneus cortices during HG, but not during EU-HI, relative to EU. Our findings may help understand brain functional adaptations to chronic hyperglycemia in diabetes, and their implications for comorbid neuropsychiatric complications.

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