Parkinson’s disease laterality impact onto the default mode network deactivation by the audio-motor transformation
Oleksii Omelchenko1, Zinayida Rozhkova2, and Iryna Karaban3
1Human and Animal Physiology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, 2Radiology, Medical Clinic BORIS, Kyiv, Ukraine, 3Department of extrapyramidal disorders, D. F. Chebotarev Institute of Herontology, Kyiv, Ukraine
Asymmetry of motor symptoms is considered a crucial
criterion for PD and influence hemisphere-associated cognitive functions. DMN was
shown to loose it’s functional connectivity in PD. We hypothesized that
AMT play important role in switching DMN to task-related deactivation state. AMT
exploration for PD laterality specific DMN connectivity analysis during movements was done. AMT and movement execution in
PD evokes activation auditory
cortex, SMN and pC. In PD patients DMN deactivates exceptionally at the period
of motor activity. pC participates as a DMN ‘hub’ and DMN deactivation
‘switching’ trigger during
AMT. PD symtoms lateralization play important role in DMN
functioning.
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