Abstract #3792

Functional brain changes in breachers following a blast-overpressure: an acute longitudinal assessment with MRI

Fatima Nasrallah^1,2, Trina Kok¹, Mary Stephenson¹, Jiesen Wang³, Alexandre Schaefer³, You Jin¹, Benjamin Thomas¹, Pamela Pun Boon Li⁴, Melissa Teo Ai Ling⁴, Julie Yeo Su Li⁴, Jia Lu⁴, John Tottman¹, and David Townsend⁵

¹Clinical Imaging Research Centre, NUS/A*STAR, Singapore, Singapore, ²Queensland Brain Institute, Queensland, Australia, ³Clinical Imaging Research Centre, NUS, Singapore, Singapore, ⁴Defense Singapore Organisation, DSO, Singapore, Singapore, ⁵clinical Imaging Research Centre, NUS/A*STAR, Singapore, Singapore

Blast injury is one of the most common types of mild traumatic brain injury. In this work we have investigated the longitudinal changes induced by a blast-overpressure injury in breacher trainers using resting state functional connectivity MRI. We show that reductions in connectivity in the Thalamic and Cerebellar regions at Day 1 following a blast are regained and increased 1 month post blast.

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