Abstract #3789

Increased activation of precuneus and posterior cingulate cortex in resting state fMRI in patients with functional movement disorders after undergoing a motor retraining program

Kwan-Jin Jung¹, Sarah Mufti², and Kathrin LaFaver²

¹Radiology, University of Louisville, Louisville, KY, United States, ²Neurology, University of Louisville, Louisville, KY, United States

Functional movement disorders (FMD) can be significantly reduced with a one-week motor retraining program. Our study compared resting state fMRI before and after treatment of 6 FMD patients. We found increased activity in the posterior default mode network, specifically the precuneus and posterior cingulate cortex, in 4 out of 6 patients after treatment, which correlated with clinical improvement of motor symptoms. Our findings suggest that restoration of normal movements in FMD patients are accompanied by increased default mode network activation.

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