Loss of functional specificity in basal ganglia in Parkinson's disease: a rs-fMRI study
Anne-Charlotte PHILIPPE1, Pierre BERROIR1, Marie VIDAILHET2, and Stéphane LEHERICY1
1Brain and Spine Institute, CENIR, INSERM U1127/CNRS UMR7225, Sorbonne Universités, UPMC, CHU Pitié-Salpêtrière, Paris, France, 2Brain and Spine Institute, INSERM U1127/CNRS UMR7225, Sorbonne Universités, UPMC, CHU Pitié-Salpêtrière, Paris, France
Loss of neuronal specificity in the basal ganglia (BG) has been reported In Parkinson’s disease (PD)[1]. However, loss of specificity has not been characterized using non-invasive methods in PD. We proposed an innovative method to characterize the functional specificity of BG. We tested the hypothesis that loss of specificity may result in larger spatial extent of overlap between anatomo-functional territories in the BG. We performed population statistics to compare the extent of overlap between PD subjects and controls. As expected, the motor territories had larger extent of overlap in PD subject than in controls revealing a loss of specificity of the BG in PD.
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