Abstract #3762

The effect of preterm birth on the thalamocortical development during the neonatal stage： A resting-state fMRI study

Yue Cai¹, Xiushuang Wu², Yuan Shi³, Lizhi Xie⁴, and Jiahong Gao⁵

¹Biomedical Engineering, Peking University, Beijing, China, People's Republic of, ²Department of Pediatrics, Daping Hospital, Third Military Medical University, Chong Qing, China, People's Republic of, ³Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China, Chong Qing, China, People's Republic of, ⁴GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of, ⁵Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China, People's Republic of

Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using the resting-state fMRI imaging analysis, we tested the hypothesis that preterm birth might to some extent affect the thalamo-cortical connections particularly in the thalamo-SM and thalamo-SA projections. Reduced thalamo-SM and increased thalamo-SA connectivity were found in the preterm newborns, and preterm with punctate white matter lesions (PWMLs) exhibited a more sever trend in the thalamo-SA projection.

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