Guangyu Chen1, Hao Shu1, Gang Chen1, Barney Douglas Ward1, Piero G Antuono2, and Shi-Jiang Li1
1biophysics, medical college of wisconsin, milwaukee, WI, United States, 2Neurology, medical college of wisconsin, milwaukee, WI, United States
A robust temporal
ordering sequence of biomarkers for staging the Alzheimer’s disease (AD) progression
risk is revealed by integrating brain function and structure, cerebrospinal
fluid (CSF), and cognition biomarkers into an event-based model. In this study,
we found that functional abnormality in the hippocampus and posterior cingulate
cortex networks is the earliest event in the preclinical phase of AD, even
antedating the detectable CSF Aβ and p-tau abnormalities; this sheds light on
the link between preclinical AD status and its symptomatic onset for accurately
identifying progressive AD trajectories along the disease
course, given the condition that disease onset is insidious.
