Abstract #3058

Comparison of Automated and Hand-Drawn Tractography of the Optic Radiations in Children with NF1-Associated Optic Pathway Gliomas

Peter de Blank^1,2, Greg Russell³, Michael J Fisher⁴, and Jeffrey I Berman⁵

¹Pediatrics, University Hospitals, Cleveland, OH, United States, ²Case Western Reserve University, Cleveland, OH, United States, ³Boston, MA, United States, ⁴Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ⁵Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Previous studies demonstrate that hand-drawn tractography of the optic radiations correlates with visual acuity in children with optic pathway glioma (OPG). However, automated tractography using a structural atlas would require less time and user expertise. We evaluated 50 children with OPG using both tractography methods. Both methods demonstrate significant differences in MD and RD between children with and without visual acuity loss. On multivariable analysis, both methods demonstrate a similar association between DTI measures and visual acuity. Automated tractography is a valid method to assess the optic radiations in children with OPG that requires less time and expertise.

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