Abstract #2984

Contrast-Enhanced Susceptibility Weighted Imaging with Ultrasmall Superparamagnetic Iron Oxide Improves the Detection of Tumour Vascularity in A HCC-LM3 Nude Mouse Model

Shuohui Yang¹, Jiang Lin¹, Fang Lu², Yuanyuan Dai¹, Zhihong Han³, and Caixia Fu⁴

¹Radiology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, People's Republic of, ²Radiology, Shuguang Hosipital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, People's Republic of, ³Pathology, Shuguang Hosipital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, People's Republic of, ⁴Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, People's Republic of

Hepatocellular carcinoma (HCC) is a hyper-vascular tumor and knowledge of the intratumoral vascularity is essential. Susceptibility weighted imaging (SWI) uses magnitude and filtered-phase information to provide high sensitivity to susceptibility changes caused by hemorrhage, calcium, iron, and small veins. It has been used to visualize normal or pathologic vascular structures that are not visible on conventional MRI. Ultrasmall superparamagnetic iron oxide (USPIO) is an intravascular blood pool contrast medium. After intravenous administration, it can cause a greater effect on local magnetic field inhomogeneities and results in higher susceptibility differences between all intratumoral vessels and the tumor on SWI. This study showed that USPIO-enhanced SWI could further enhance the demonstration of tumor vascularity inside HCC when compared to unenhanced SWI in an orthotopic xenograft nude mice HCC model.

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