QUANTITATIVE SUSCEPTIBILITY MAPPING OF THE LIVER AND SPLEEN IN SUBJECTS WITH FERUMOXYTOL INJECTION
Samir D. Sharma1, Timothy J. Colgan1, Camilo A. Campo1, Tilman Schubert1, Utaroh Motosugi2, Diego Hernando1, and Scott B. Reeder1,3
1Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Radiology, University of Yamanashi, Yamanashi, Japan, 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States
Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) agent
that is taken up by the reticuloendothelial system where
it accumulates in organs such as the liver, spleen, and bone marrow. Given the
superparamagnetic properties of ferumoxytol, it may be possible for
quantitative susceptibility mapping (QSM) techniques to detect and quantify the
concentration of ferumoxytol in these organs. Recent technical developments have
demonstrated the feasibility of a QSM technique for magnetic susceptibility
mapping of the abdomen. Thus, the purpose of this work was to
test the feasibility of QSM to assess the longitudinal changes of ferumoxytol
in the liver and spleen.
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