Increasing the inhomogeneous magnetization transfer (ihMT) signal in vivo with high amplitude, low duty cycle irradiation
Gopal Varma1, Olivier M Girard2, Valentin H Prevost2, Guillaume Duhamel2, and David C Alsop1
1Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2CRMBM-CEMEREM UMR 7339, CNRS-AMU, Aix Marseille Université, Marseille, France
High
power, off-resonance irradiation as utilized in ihMT/MT can saturate pools of
bound magnetization before they exchange in tissues. Observation of such
saturation phenomena is limited by power constraints in-vivo and by attenuation
of the free pool magnetization. A technique for studying and enhancing
saturation effects using relatively short bursts of higher power irradiation is
evaluated. The results provided 2-5 fold increases in ihMTR (depending
on average power and offset frequency). Such short duration, high power pulses
offer a new window to probe exchange kinetics and dipolar order effects, as well as enhancing the quality and feasibility of ihMT imaging.
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