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Abstract #2889

Noninvasive Assessment of Renal Fibrosis Using Magnetization Transfer MRI in Murine Renal Artery Stenosis

Kai Jiang1, Christopher M. Ferguson1, Behzad Ebrahimi1, Hui Tang1, Timothy L. Kline2, Prassana K. Mishra3, Joseph P. Grande4, Slobodan I. Macura3, and Lilach O. Lerman1

1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States, 3Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States, 4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States

In this study, magnetization transfer was used to measure renal fibrosis in a murine model of renal artery stenosis. A collagen phantom study was performed to optimize the irradiation-offset frequency of MT pulses. Renal fibrosis by in vivo MT and ex vivo histology or hydroxproline assay showed a good correlation, suggesting that MT could be used to assess renal fibrosis. In addition, MT successfully captured the physiological changes at different stages of renal fibrosis, indicating that MT was capable of monitoring the longitudinal development of functionally significant renal fibrosis.

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