Measurement of Absolute Cerebral Blood Volume using Velocity-Selective Pulse Trains
Feng Xu1,2 and Qin Qin1,2
1Radiology, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
Current MRI techniques for quantification of absolute cerebral
blood volume (CBV) are all contrast-based. To reduce associated risks and cost,
we proposed a non-contrast-enhanced
(NCE) MRI method using a velocity-selective (VS)
spin labeling approach for CBV measurement at 3T. Gray matter CBV values across
5 subjects are 2.4±0.2 mL/100g for
blood flowing between the encoded cutoff velocities of 0.5cm/s and 3.1cm/s, with
a GM/WM ratio of 1.9±0.3.
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