Hassan Bagher-Ebadian1,2, Ana deCarvalho1, Tavarekere Nagaraja1, Azimeh NV Dehkordi3, Susan Irtenkauf1, Swayamparva Panda1, Robert Knight1, and James R Ewing1,2
1Henry Ford Hospital, Detroit, MI, United States, 2Oakland University, Rochester, MI, United States, 3Shahid Beheshti University, Tehran, Iran
In
human glioblastoma multiforme (GBM), infiltrating cells are found in remote
locations, even in the hemisphere contralateral to the primary lesion. Although MRI allows approximation of the
extent of tumor cell infiltration, the actual extent of infiltration may be
greater or less than the edema, and there is no standard MRI practice that can
be used to assess the infiltrating tumor burden. This pilot study investigates
the feasibility of using a set of MR modalities for the development of an MRI
estimate of infiltrating tumor burden in Patient-Derived Mouse Xenografts model
of GBM using an adaptive model.
