Abstract #2777

DWI and DCE-MRI for imaging diagnosis on vasculogenic mimicry and predicting responses to vascular-disrupting therapy on primary liver cancers in rats

Yewei Liu^1,2, Ting Yin¹, Yuanbo Feng¹, Jie Yu¹, Gang Huang², Jianjun Liu², Shaoli Song², Johannes V Swinnen³, Guy Bormans⁴, Uwe Himmelreich⁵, Raymond Oyen⁶, and Yicheng Ni¹

¹Theragnostic Laboratory, MoSAIC, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium, ²Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Department of Nuclear Medicine, Shanghai, China, People's Republic of, ³Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁵Biomedical MRI, MoSAIC, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁶Radiology, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium

Vasculogenic mimicry (VM) refers to tumor cells mimicking endothelial cells and directly participating in blood vessel formation, which appears in 2 distinctive forms, namely, the tubular type and the patterned matrix type. In liver cancer, VM is associated with tumor aggressiveness and poor clinical outcome. DENA-induced primary liver cancer model in rat appears an optimal VM model with both the 2 VM types. DWI and DCE-MRI were used to characterize and distinguish different VM types, and sensitively predicting diverse therapeutic responses to a vascular-disrupting agent CA4P.

This abstract and the presentation materials are available to members only; a login is required.

Join Here