31P spectroscopic imaging for evaluation of early effects of photodynamic treatment on tumor metabolism
Tom Schreurs1, Sophie Peereboom2, Gustav Strijkers3, Jeanine Prompers1, and Klaas Nicolay1
1Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Biomedical Engineering, ETH Zürich, Zürich, Switzerland, 3Bioengineering and Physics, Academic Medical Center Amsterdam, Amsterdam, Netherlands
The
feasibility of 31P spectroscopic imaging to evaluate effects of photodynamic
therapy (PDT) on tumor metabolism was assessed. In PDT, a light-activated drug and local
laser irradiation are used to ablate tumors. Spectroscopic imaging was used to
visualize ATP and Pi after PDT in a mouse tumor model before, during, and up to
1 day after PDT. Treatment was performed inside the 9.4T scanner. Clear changes
in phosphorus metabolite signals were already observed at 20 min after PDT,
indicating a rapid decrease in energetic status. Moreover, the potential of spectroscopic
imaging to detect spatial heterogeneities in these changes was demonstrated.
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